The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization
Abstract During preimplantation development, contractile forces generated at the apical cortex segregate cells into inner and outer positions of the embryo, establishing the inner cell mass 30" Double Wall Oven (ICM) and trophectoderm.To which extent these forces influence ICM-trophectoderm fate remains unresolved.Here, we found that the nuclear la